Bos taurus Gene: CFD
Summary
InnateDB Gene IDBG-645537.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CFD
Gene Name Complement factor D
Synonyms DF;
Species Bos taurus
Ensembl Gene ENSBTAG00000048122
Encoded Proteins
Complement factor D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197766:
The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:45030310-45032845
Strand Forward strand
Band
Transcripts
ENSBTAT00000063284 ENSBTAP00000055802
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0002376 immune system process
GO:0006508 proteolysis
GO:0006957 complement activation, alternative pathway
GO:0045087 innate immune response
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Platelet degranulation pathway
Initial triggering of complement pathway
Hemostasis pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Alternative complement activation pathway
Complement cascade pathway
Innate Immune System pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Alternative complement activation pathway
Innate Immune System pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Immune System pathway
Response to elevated platelet cytosolic Ca2+ pathway
Complement cascade pathway
Initial triggering of complement pathway
Hemostasis pathway
Platelet degranulation pathway
Innate Immune System pathway
Complement cascade pathway
Hemostasis pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Alternative complement activation pathway
Initial triggering of complement pathway
Response to elevated platelet cytosolic Ca2+ pathway
KEGG
Complement and coagulation cascades pathway
Staphylococcus aureus infection pathway
Complement and coagulation cascades pathway
Staphylococcus aureus infection pathway
INOH
PID BIOCARTA
Alternative complement pathway [Biocarta view]
PID NCI
Cross-References
SwissProt Q3T0A3
TrEMBL
UniProt Splice Variant
Entrez Gene 505647
UniGene Bt.41326
RefSeq NM_001034255 XM_005209262
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102479
GenPept AAI02480
RNA Seq Atlas 505647
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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