Mus musculus Gene: Cfd
Summary
InnateDB Gene IDBG-171424.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cfd
Gene Name complement factor D (adipsin)
Synonyms Adn; DF;
Species Mus musculus
Ensembl Gene ENSMUSG00000061780
Encoded Proteins
complement factor D (adipsin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197766:
The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:79890853-79892656
Strand Forward strand
Band C1
Transcripts
ENSMUST00000061653 ENSMUSP00000056836
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006957 complement activation, alternative pathway
Cellular Component
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Platelet degranulation pathway
Innate Immune System pathway
Complement cascade pathway
Hemostasis pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Alternative complement activation pathway
Initial triggering of complement pathway
Response to elevated platelet cytosolic Ca2+ pathway
KEGG
Complement and coagulation cascades pathway
Staphylococcus aureus infection pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Alternative complement activation pathway
Innate Immune System pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Immune System pathway
Response to elevated platelet cytosolic Ca2+ pathway
Complement cascade pathway
Initial triggering of complement pathway
Hemostasis pathway
Platelet degranulation pathway
Initial triggering of complement pathway
Hemostasis pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Alternative complement activation pathway
Complement cascade pathway
Innate Immune System pathway
KEGG
Complement and coagulation cascades pathway
Staphylococcus aureus infection pathway
INOH
PID BIOCARTA
Alternative complement pathway [Biocarta view]
PID NCI
Cross-References
SwissProt P03953
TrEMBL B7ZNS9 Q3UP47
UniProt Splice Variant
Entrez Gene 11537
UniGene
RefSeq NM_001291915 NM_013459
OMIM
CCDS CCDS23995
HPRD
IMGT
MGI ID MGI:87931
MGI Symbol Cfd
EMBL AK143817 BC138778 BC138779 BC145412 CH466553 M11768 M13386 X04673
GenPept AAA37262 AAA40486 AAI38779 AAI38780 AAI45413 BAE25550 CAA28378 CAA28379 EDL31632 EDL31634
RNA Seq Atlas 11537