InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CFD

Summary

InnateDB Protein

IDBP-698244.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CFD

Protein Name

Complement factor D

Synonyms

DF;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000055802

InnateDB Gene

IDBG-645537 (CFD)

Protein Structure

UniProt Annotation

Function

Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0016787	hydrolase activity

Biological Process

GO:0002376	immune system process
GO:0006508	proteolysis
GO:0006957	complement activation, alternative pathway
GO:0045087	innate immune response

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

InterPro

IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel

PFAM

PF00089
PF09342

PRINTS

PR00722

PIRSF

SMART

SM00020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3T0A3

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

505647

UniGene

Bt.41326

RefSeq

NP_001029427

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102479

GenPept

AAI02480