InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UBE2E1

Summary

InnateDB Gene

IDBG-22029.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2E1

Gene Name

ubiquitin-conjugating enzyme E2E 1

Synonyms

UBCH6

Species

Homo sapiens

Ensembl Gene

ENSG00000170142

Encoded Proteins

IDBP-22031

ubiquitin-conjugating enzyme E2E 1

IDBP-22033

ubiquitin-conjugating enzyme E2E 1

IDBP-367653

ubiquitin-conjugating enzyme E2E 1

IDBP-367660

ubiquitin-conjugating enzyme E2E 1

IDBP-367666

ubiquitin-conjugating enzyme E2E 1

IDBP-806800

ubiquitin-conjugating enzyme E2E 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:23805903-23891316

Strand

Forward strand

Band

p24.2

Transcripts

ENST00000306627	ENSP00000303709
ENST00000346855	ENSP00000329113
ENST00000442670	ENSP00000410652
ENST00000424381	ENSP00000411351
ENST00000452012	ENSP00000393088
ENST00000484048
ENST00000495141
ENST00000481622
ENST00000467766	ENSP00000475890
ENST00000475680
ENST00000493707

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 119 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	119 [view]
Protein-Protein	119 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity
GO:0042296	ISG15 ligase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0000278	mitotic cell cycle
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007094	mitotic spindle assembly checkpoint
GO:0008152	metabolic process
GO:0010390	histone monoubiquitination
GO:0016567	protein ubiquitination
GO:0019221	cytokine-mediated signaling pathway
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0032020	ISG15-protein conjugation
GO:0033523	histone H2B ubiquitination
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070936	protein K48-linked ubiquitination