InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBE2E1

Summary

InnateDB Protein

IDBP-22031.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2E1

Protein Name

ubiquitin-conjugating enzyme E2E 1

Synonyms

UBCH6;

Species

Homo sapiens

Ensembl Protein

ENSP00000303709

InnateDB Gene

IDBG-22029 (UBE2E1)

Protein Structure

UniProt Annotation

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. {ECO:0000269PubMed:16428300, ECO:0000269PubMed:20061386}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:18845142}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 119 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	119 [view]
Protein-Protein	119 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity
GO:0042296	ISG15 ligase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0000278	mitotic cell cycle
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007094	mitotic spindle assembly checkpoint
GO:0010390	histone monoubiquitination
GO:0016567	protein ubiquitination
GO:0019221	cytokine-mediated signaling pathway
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0032020	ISG15-protein conjugation
GO:0033523	histone H2B ubiquitination
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070936	protein K48-linked ubiquitination