InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: YES1

Summary

InnateDB Protein

IDBP-727406.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YES1

Protein Name

Synonyms

c-yes; HsT441; P61-YES; Yes;

Species

Homo sapiens

Ensembl Protein

ENSP00000464380

InnateDB Gene

IDBG-363 (YES1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	70 [view]
Protein-Protein	68 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019899	enzyme binding
GO:0044325	ion channel binding

Biological Process

GO:0006464	cellular protein modification process
GO:0006468	protein phosphorylation
GO:0007596	blood coagulation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0031295	T cell costimulation
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043114	regulation of vascular permeability
GO:0045087	innate immune response
GO:0050900	leukocyte migration

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM