InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: YES1

Summary

InnateDB Gene

IDBG-363.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YES1

Gene Name

v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1

Synonyms

c-yes; HsT441; P61-YES; Yes

Species

Homo sapiens

Ensembl Gene

ENSG00000176105

Encoded Proteins

IDBP-367

v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1

IDBP-726465

IDBP-727406

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:721588-812546

Strand

Reverse strand

Band

p11.32

Transcripts

ENST00000314574	ENSP00000324740
ENST00000584307	ENSP00000462468
ENST00000581960
ENST00000577961	ENSP00000464380
ENST00000577611

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	70 [view]
Protein-Protein	68 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019899	enzyme binding
GO:0044325	ion channel binding

Biological Process

GO:0006464	cellular protein modification process
GO:0006468	protein phosphorylation
GO:0007596	blood coagulation
GO:0015758	glucose transport
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0031295	T cell costimulation
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043114	regulation of vascular permeability
GO:0045087	innate immune response
GO:0046777	protein autophosphorylation
GO:0050900	leukocyte migration

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome