InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: STK11

Summary

InnateDB Protein

IDBP-698332.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STK11

Protein Name

serine/threonine kinase 11

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015459

InnateDB Gene

IDBG-645610 (STK11)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0002039	p53 binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030275	LRR domain binding
GO:0030295	protein kinase activator activity

Biological Process

GO:0001558	regulation of cell growth
GO:0001894	tissue homeostasis
GO:0001944	vasculature development
GO:0006468	protein phosphorylation
GO:0007050	cell cycle arrest
GO:0007286	spermatid development
GO:0008285	negative regulation of cell proliferation
GO:0010212	response to ionizing radiation
GO:0030010	establishment of cell polarity
GO:0030111	regulation of Wnt signaling pathway
GO:0030308	negative regulation of cell growth
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032147	activation of protein kinase activity
GO:0036399	TCR signalosome assembly
GO:0042593	glucose homeostasis
GO:0043276	anoikis
GO:0045059	positive thymic T cell selection
GO:0046777	protein autophosphorylation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050772	positive regulation of axonogenesis
GO:0050852	T cell receptor signaling pathway
GO:0051645	Golgi localization
GO:0051896	regulation of protein kinase B signaling
GO:0060070	canonical Wnt signaling pathway
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0016020	membrane
GO:0036398	TCR signalosome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt