InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: STK11

Summary

InnateDB Gene

IDBG-645610.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STK11

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011639

Encoded Proteins

IDBP-698332

serine/threonine kinase 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118046:
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:45282199-45289554

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000015459

ENSBTAP00000015459

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0002039	p53 binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030275	LRR domain binding
GO:0030295	protein kinase activator activity

Biological Process

GO:0001558	regulation of cell growth
GO:0001894	tissue homeostasis
GO:0001944	vasculature development
GO:0006468	protein phosphorylation
GO:0007050	cell cycle arrest
GO:0007286	spermatid development
GO:0008285	negative regulation of cell proliferation
GO:0010212	response to ionizing radiation
GO:0030010	establishment of cell polarity
GO:0030111	regulation of Wnt signaling pathway
GO:0030308	negative regulation of cell growth
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032147	activation of protein kinase activity
GO:0036399	TCR signalosome assembly
GO:0042593	glucose homeostasis
GO:0043276	anoikis
GO:0045059	positive thymic T cell selection
GO:0046777	protein autophosphorylation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050772	positive regulation of axonogenesis
GO:0050852	T cell receptor signaling pathway
GO:0051645	Golgi localization
GO:0051896	regulation of protein kinase B signaling
GO:0060070	canonical Wnt signaling pathway
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0016020	membrane
GO:0036398	TCR signalosome
GO:0070062	extracellular vesicular exosome