InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TH

Summary

InnateDB Protein

IDBP-697926.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

tyrosine 3-monooxygenase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000038050

InnateDB Gene

IDBG-645229 (TH)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0004511	tyrosine 3-monooxygenase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

Biological Process

GO:0001666	response to hypoxia
GO:0001963	synaptic transmission, dopaminergic
GO:0007507	heart development
GO:0007601	visual perception
GO:0007612	learning
GO:0007613	memory
GO:0007617	mating behavior
GO:0007626	locomotory behavior
GO:0008016	regulation of heart contraction
GO:0009072	aromatic amino acid family metabolic process
GO:0009887	organ morphogenesis
GO:0042416	dopamine biosynthetic process
GO:0042418	epinephrine biosynthetic process
GO:0042421	norepinephrine biosynthetic process
GO:0042423	catecholamine biosynthetic process
GO:0042462	eye photoreceptor cell development
GO:0042755	eating behavior
GO:0045471	response to ethanol
GO:0048596	embryonic camera-type eye morphogenesis
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005790	smooth endoplasmic reticulum
GO:0009898	cytoplasmic side of plasma membrane
GO:0030424	axon
GO:0031410	cytoplasmic vesicle
GO:0033162	melanosome membrane
GO:0043005	neuron projection
GO:0043204	perikaryon

Protein Structure and Domains

PDB ID

InterPro

IPR005962 Tyrosine 3-monooxygenase
IPR019773 Tyrosine 3-monooxygenase-like
IPR019774 Aromatic amino acid hydroxylase, C-terminal
IPR021164 Tyrosine hydroxylase, conserved site

PFAM

PF00351
PF12549

PRINTS

PR00372

PIRSF

PIRSF000336

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt