Bos taurus Gene: TH
Summary
InnateDB Gene IDBG-645229.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TH
Gene Name tyrosine 3-monooxygenase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000026768
Encoded Proteins
tyrosine 3-monooxygenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180176:
The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:50027265-50034123
Strand Forward strand
Band
Transcripts
ENSBTAT00000038235 ENSBTAP00000038050
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0004511 tyrosine 3-monooxygenase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Biological Process
GO:0001666 response to hypoxia
GO:0001963 synaptic transmission, dopaminergic
GO:0007507 heart development
GO:0007601 visual perception
GO:0007612 learning
GO:0007613 memory
GO:0007617 mating behavior
GO:0007626 locomotory behavior
GO:0008016 regulation of heart contraction
GO:0009072 aromatic amino acid family metabolic process
GO:0009887 organ morphogenesis
GO:0042416 dopamine biosynthetic process
GO:0042418 epinephrine biosynthetic process
GO:0042421 norepinephrine biosynthetic process
GO:0042423 catecholamine biosynthetic process
GO:0042462 eye photoreceptor cell development
GO:0042755 eating behavior
GO:0045471 response to ethanol
GO:0048596 embryonic camera-type eye morphogenesis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005790 smooth endoplasmic reticulum
GO:0009898 cytoplasmic side of plasma membrane
GO:0030424 axon
GO:0031410 cytoplasmic vesicle
GO:0033162 melanosome membrane
GO:0043005 neuron projection
GO:0043204 perikaryon
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Amine-derived hormones pathway
Metabolism of amino acids and derivatives pathway
Metabolism pathway
Catecholamine biosynthesis pathway
Catecholamine biosynthesis pathway
Metabolism pathway
Metabolism of amino acids and derivatives pathway
Amine-derived hormones pathway
KEGG
Tyrosine metabolism pathway
Parkinson's disease pathway
Tyrosine metabolism pathway
Parkinson's disease pathway
INOH
Tyrosine metabolism pathway
PID BIOCARTA
PID NCI
Alpha-synuclein signaling
ATF-2 transcription factor network
AP-1 transcription factor network
p38 signaling mediated by MAPKAP kinases
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_173884 XM_005227268
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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