InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TH

Summary

InnateDB Gene

IDBG-645229.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

tyrosine 3-monooxygenase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000026768

Encoded Proteins

IDBP-697926

tyrosine 3-monooxygenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180176:
The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:50027265-50034123

Strand

Forward strand

Band

Transcripts

ENSBTAT00000038235

ENSBTAP00000038050

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0004511	tyrosine 3-monooxygenase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

Biological Process

GO:0001666	response to hypoxia
GO:0001963	synaptic transmission, dopaminergic
GO:0007507	heart development
GO:0007601	visual perception
GO:0007612	learning
GO:0007613	memory
GO:0007617	mating behavior
GO:0007626	locomotory behavior
GO:0008016	regulation of heart contraction
GO:0009072	aromatic amino acid family metabolic process
GO:0009887	organ morphogenesis
GO:0042416	dopamine biosynthetic process
GO:0042418	epinephrine biosynthetic process
GO:0042421	norepinephrine biosynthetic process
GO:0042423	catecholamine biosynthetic process
GO:0042462	eye photoreceptor cell development
GO:0042755	eating behavior
GO:0045471	response to ethanol
GO:0048596	embryonic camera-type eye morphogenesis
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005790	smooth endoplasmic reticulum
GO:0009898	cytoplasmic side of plasma membrane
GO:0030424	axon
GO:0031410	cytoplasmic vesicle
GO:0033162	melanosome membrane
GO:0043005	neuron projection
GO:0043204	perikaryon