Bos taurus Protein: EEF2
Summary
InnateDB Protein IDBP-696958.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EEF2
Protein Name Elongation factor 2
Synonyms EF-2;
Species Bos taurus
Ensembl Protein ENSBTAP00000005581
InnateDB Gene IDBG-644322 (EEF2)
Protein Structure
UniProt Annotation
Function Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 84 interaction(s) predicted by orthology.
Predicted by orthology
Total 84 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008494 translation activator activity
GO:0019901 protein kinase binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006412 translation
GO:0006414 translational elongation
GO:0010628 positive regulation of gene expression
GO:0045727 positive regulation of translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005844 polysome
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000640 Translation elongation factor EFG, V domain
IPR000795 Elongation factor, GTP-binding domain
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR005225 Small GTP-binding protein domain
IPR005517 Translation elongation factor EFG/EF2, domain IV
IPR009000 Translation protein, beta-barrel domain
IPR009022 Elongation factor G, III-V domain
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00679
PF00009
PF03144
PF03764
PF14492
PRINTS PR00315
PIRSF
SMART SM00838
SM00889
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3SYU2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281138
UniGene Bt.39668
RefSeq NP_001068589
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103385
GenPept AAI03386