InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.66498

Summary

InnateDB Protein

IDBP-680493.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.66498

Protein Name

interleukin 6 signal transducer (gp130, oncostatin M receptor)

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000023595

InnateDB Gene

IDBG-629050 (BT.66498)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0004897	ciliary neurotrophic factor receptor activity
GO:0004915	interleukin-6 receptor activity
GO:0004921	interleukin-11 receptor activity
GO:0004923	leukemia inhibitory factor receptor activity
GO:0004924	oncostatin-M receptor activity
GO:0005127	ciliary neurotrophic factor receptor binding
GO:0005138	interleukin-6 receptor binding
GO:0005515	protein binding
GO:0019838	growth factor binding
GO:0019970	interleukin-11 binding
GO:0019981	interleukin-6 binding

Biological Process

GO:0005977	glycogen metabolic process
GO:0007165	signal transduction
GO:0008284	positive regulation of cell proliferation
GO:0008593	regulation of Notch signaling pathway
GO:0019221	cytokine-mediated signaling pathway
GO:0034097	response to cytokine
GO:0038154	interleukin-11-mediated signaling pathway
GO:0038165	oncostatin-M-mediated signaling pathway
GO:0042102	positive regulation of T cell proliferation
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045669	positive regulation of osteoblast differentiation
GO:0048711	positive regulation of astrocyte differentiation
GO:0048861	leukemia inhibitory factor signaling pathway
GO:0070102	interleukin-6-mediated signaling pathway
GO:0070104	negative regulation of interleukin-6-mediated signaling pathway
GO:0070106	interleukin-27-mediated signaling pathway
GO:0070120	ciliary neurotrophic factor-mediated signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005896	interleukin-6 receptor complex
GO:0005900	oncostatin-M receptor complex
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome
GO:0070110	ciliary neurotrophic factor receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR003961 Fibronectin, type III
IPR010457 Immunoglobulin C2-set-like, ligand-binding
IPR015152 Growth hormone/erythropoietin receptor, ligand binding
IPR015321 Interleukin-6 receptor alpha, binding

PFAM

PF00041
PF01108
PF06328
PF09067
PF09240

PRINTS

PIRSF

SMART

SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite