Version 5.4
| Bos taurus Gene: BT.66498 | |||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-629050.3 | ||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||
| Gene Symbol | BT.66498 | ||||||||||||||||||||||||||||||||||||
| Gene Name | Uncharacterized protein | ||||||||||||||||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000017745 | ||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
interleukin 6 signal transducer (gp130, oncostatin M receptor)
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| Protein Structure | |||||||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] IL6ST (GP130) is a common cytokine receptor subunit that is preferentially bound by SOCS3 on its SHP2-binding site, suggesting that some of the negative regulatory roles previously attributed to the phosphatase SHP-2 might in fact be caused by the action of SOCS3.
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| Entrez Gene | |||||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134352:
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2010] The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 20:23212633-23270316 | ||||||||||||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||||||||||||
| Band | |||||||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||
| NETPATH |
AndrogenReceptor pathway
IL6 pathway
IL11 pathway
Oncostatin_M pathway
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| REACTOME |
Interleukin-6 signaling pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Signaling by Interleukins pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Signaling by ERBB2 pathway
Disease pathway
SHC-related events pathway
RAF/MAP kinase cascade pathway
Signaling by GPCR pathway
Signaling by Insulin receptor pathway
Interleukin-2 signaling pathway
MyD88 cascade initiated on plasma membrane pathway
Signaling by VEGF pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SHC1 events in ERBB2 signaling pathway
Cytokine Signaling in Immune system pathway
VEGFR2 mediated cell proliferation pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
SHC-mediated signalling pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
ERK activation pathway
ERK1 activation pathway
SHC1 events in ERBB4 signaling pathway
Signalling to RAS pathway
SHC1 events in EGFR signaling pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Signaling by EGFR pathway
Frs2-mediated activation pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
VEGFA-VEGFR2 Pathway pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
Toll-Like Receptors Cascades pathway
Signalling to ERKs pathway
Signaling by Interleukins pathway
Interleukin-6 signaling pathway
MyD88 dependent cascade initiated on endosome pathway
Signalling by NGF pathway
Signaling by PDGF pathway
FRS2-mediated cascade pathway
Developmental Biology pathway
SOS-mediated signalling pathway
Activated TLR4 signalling pathway
IRS-related events pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-mediated signalling pathway
ERK2 activation pathway
ARMS-mediated activation pathway
MyD88-independent cascade pathway
Signal Transduction pathway
GRB2 events in ERBB2 signaling pathway
Signaling by Leptin pathway
Prolonged ERK activation events pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Signaling by FGFR pathway
GRB2 events in EGFR signaling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
FCERI mediated MAPK activation pathway
SHC-related events triggered by IGF1R pathway
Signaling by EGFR in Cancer pathway
NCAM signaling for neurite out-growth pathway
Signalling to p38 via RIT and RIN pathway
DAP12 interactions pathway
DAP12 signaling pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
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| INOH |
JAK STAT pathway and regulation pathway
IL-6 signaling pathway
LIF signaling pathway
JAK STAT pathway and regulation pathway
IL-6 signaling pathway
LIF signaling pathway
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| PID NCI |
IL27-mediated signaling events
SHP2 signaling
IL6-mediated signaling events
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| Cross-References | |||||||||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||||||||
| TrEMBL | E1BD36 | ||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||
| Entrez Gene | 522155 | ||||||||||||||||||||||||||||||||||||
| UniGene | |||||||||||||||||||||||||||||||||||||
| RefSeq | XM_002696322 XM_600430 | ||||||||||||||||||||||||||||||||||||
| HUGO | HGNC:6021 | ||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||
| EMBL | DAAA02050335 DAAA02050336 DAAA02050337 | ||||||||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | 522155 | ||||||||||||||||||||||||||||||||||||