InnateDB Protein
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IDBP-537900.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Iqsec1
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Protein Name
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IQ motif and Sec7 domain 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000118802
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InnateDB Gene
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IDBG-169366 (Iqsec1)
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Protein Structure
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Function |
In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin. {ECO:0000250}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005086
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ARF guanyl-nucleotide exchange factor activity
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GO:0005515
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protein binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1196356
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InterPro |
IPR000048
IQ motif, EF-hand binding site
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PFAM |
PF00612
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PRINTS |
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PIRSF |
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SMART |
SM00015
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TIGRFAMs |
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Modification |
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SwissProt |
Q8R0S2
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PhosphoSite |
PhosphoSite-Q8R0S2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
232227
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UniGene |
Mm.196943
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RefSeq |
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MGI ID |
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MGI Symbol |
Iqsec1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AC121954
AK157963
AK220355
BC026481
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GenPept |
AAH26481
BAD90418
BAE34286
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