InnateDB Protein
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IDBP-257704.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ndrg2
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Protein Name
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N-myc downstream regulated gene 2
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Synonyms
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AI182517; AU040374; Ndr2; SYLD;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000107259
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InnateDB Gene
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IDBG-157751 (Ndrg2)
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Protein Structure
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Function |
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:14985363, ECO:0000269PubMed:16520977}. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed at highest levels in brain, heart and liver, and at lower levels in kidney, colon, skeletal muscle, adrenal gland, ovary and uterus (at protein level). {ECO:0000269PubMed:15461589, ECO:0000269PubMed:16520977, ECO:0000269PubMed:21636852}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
GO:0001818
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negative regulation of cytokine production
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GO:0007399
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nervous system development
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GO:0010574
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regulation of vascular endothelial growth factor production
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GO:0016055
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Wnt signaling pathway
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GO:0030154
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cell differentiation
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GO:0048662
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negative regulation of smooth muscle cell proliferation
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GO:0070373
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negative regulation of ERK1 and ERK2 cascade
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GO:0090361
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regulation of platelet-derived growth factor production
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Cellular Component |
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PDB ID |
MGI:1352498
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InterPro |
IPR004142
NDRG
IPR029058
Alpha/Beta hydrolase fold
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PFAM |
PF03096
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9QYG0
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PhosphoSite |
PhosphoSite-Q9QYG0
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TrEMBL |
Q9CTJ5
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UniProt Splice Variant |
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Entrez Gene |
29811
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UniGene |
Mm.416503
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RefSeq |
NP_001139431
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MGI ID |
2QMQ
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MGI Symbol |
Ndrg2
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OMIM |
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CCDS |
CCDS49486
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HPRD |
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IMGT |
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EMBL |
AB033921
AK003364
AK076514
AK154597
AK158900
AK168011
AK173136
BC012963
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GenPept |
AAH12963
BAA85882
BAB22738
BAC36373
BAD32414
BAE32700
BAE34721
BAE39998
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