InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ndrg2

Summary

InnateDB Gene

IDBG-157751.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndrg2

Gene Name

N-myc downstream regulated gene 2

Synonyms

AI182517; AU040374; Ndr2; SYLD

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004558

Encoded Proteins

IDBP-157753

N-myc downstream regulated gene 2

IDBP-257704

N-myc downstream regulated gene 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165795:
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:51905271-51913488

Strand

Reverse strand

Band

Transcripts

ENSMUST00000004673	ENSMUSP00000004673
ENSMUST00000111632	ENSMUSP00000107259

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001818	negative regulation of cytokine production
GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0010574	regulation of vascular endothelial growth factor production
GO:0016055	Wnt signaling pathway
GO:0021762	substantia nigra development
GO:0030154	cell differentiation
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0090361	regulation of platelet-derived growth factor production

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0030426	growth cone
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000165795

View Gene Order

ENSBTAG00000000843

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

myc_represspathway

Validated targets of C-MYC transcriptional repression

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.26722 Mm.416503

RefSeq

NM_001145959 NM_013864 XM_006519098 XM_006519099 XM_006519100 XM_006519101 XM_006519102 XM_006519103 XM_006519104 XM_006519105 XM_006534650 XM_006534651 XM_006534652 XM_006534653 XM_006534654 XM_006534655 XM_006534656

OMIM

CCDS

CCDS27047 CCDS49486

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas