Version 5.4
Mus musculus Protein: Wdhd1
Summary
InnateDB Protein IDBP-257360.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wdhd1
Protein Name WD repeat and HMG-box DNA binding protein 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000107420
InnateDB Gene IDBG-154219 (Wdhd1)
Protein Structure
UniProt Annotation
Function Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. {ECO:0000250}.
Subcellular Localization Nucleus, nucleoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0070063 RNA polymerase binding
Biological Process
GO:0006396 RNA processing
GO:0033044 regulation of chromosome organization
GO:0070829 heterochromatin maintenance
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0005654 nucleoplasm
Protein Structure and Domains
PDB ID MGI:2443514
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR021717 Nucleoporin Nup120/160
IPR022100 Protein of unknown function DUF3639
PFAM PF00400
PF11715
PF12341
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P59328
PhosphoSite PhosphoSite-P59328
TrEMBL
UniProt Splice Variant
Entrez Gene 218973
UniGene Mm.265615
RefSeq
MGI ID
MGI Symbol Wdhd1
OMIM
CCDS
HPRD
IMGT
EMBL AK036390 AK052690 BC063740
GenPept AAH63740 BAC29408 BAC35097

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca