Mus musculus Protein: Epha5 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-174720.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Epha5 | ||||||||||||||||||||||
Protein Name | Eph receptor A5 | ||||||||||||||||||||||
Synonyms | AI854630; AW125296; bsk; Cek7; Ehk1; Els1; Hek7; Rek7; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000060646 | ||||||||||||||||||||||
InnateDB Gene | IDBG-174718 (Epha5) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino- hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose- stimulated insulin secretion. {ECO:0000269PubMed:12124402, ECO:0000269PubMed:17448994}. | ||||||||||||||||||||||
Subcellular Localization | Cell membrane; Single-pass type I membrane protein. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Specifically expressed in the brain. Highly expressed in hippocampus, tenia tecta, indusium griseum and piriform cortex. The highest level of expression is found in the CA3 region of the hippocampus and the pyramidal cell layer of the piriform cortex. In addition, elevated levels of expression are also found in amygdala, medial septum, nucleus of the diagonal band, and in olfactory bulb. Expressed in pancreatic islet cells (at protein level). {ECO:0000269PubMed:17448994, ECO:0000269PubMed:8145300}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:99654 | ||||||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR001090 Ephrin receptor ligand binding domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR001660 Sterile alpha motif domain IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain IPR003961 Fibronectin, type III IPR008979 Galactose-binding domain-like IPR011009 Protein kinase-like domain IPR011510 Sterile alpha motif, type 2 IPR013761 Sterile alpha motif/pointed domain IPR020635 Tyrosine-protein kinase, catalytic domain IPR021129 Sterile alpha motif, type 1 |
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PFAM |
PF00069
PF01404 PF07714 PF00041 PF01108 PF07647 PF00536 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||||||
SMART |
SM00615
SM00454 SM00220 SM00060 SM00219 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q60629 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q60629 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 13839 | ||||||||||||||||||||||
UniGene | Mm.137991 | ||||||||||||||||||||||
RefSeq | NP_031963 | ||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Epha5 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS19376 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC101956 AC114638 AC129220 AC132597 U07357 | ||||||||||||||||||||||
GenPept | AAA17038 | ||||||||||||||||||||||