InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc34a2

Summary

InnateDB Protein

IDBP-164378.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc34a2

Protein Name

solute carrier family 34 (sodium phosphate), member 2

Synonyms

AA536683; D5Ertd227e; NaPi-2b; Npt2b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000092380

InnateDB Gene

IDBG-164374 (Slc34a2)

Protein Structure

UniProt Annotation

Function

May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highly abundant in the ileum of small intestine, whereas it is almost absent in the duodenum and in the jejunum. {ECO:0000269PubMed:15701623}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005436	sodium:phosphate symporter activity
GO:0015321	sodium-dependent phosphate transmembrane transporter activity
GO:0019904	protein domain specific binding
GO:0031402	sodium ion binding
GO:0042301	phosphate ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006817	phosphate ion transport
GO:0007568	aging
GO:0009750	response to fructose
GO:0030643	cellular phosphate ion homeostasis
GO:0032355	response to estradiol
GO:0035435	phosphate ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0043627	response to estrogen
GO:0044341	sodium-dependent phosphate transport

Cellular Component

GO:0005903	brush border
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane
GO:0031528	microvillus membrane