InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ctdp1

Summary

InnateDB Protein

IDBP-161410.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctdp1

Protein Name

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1

Synonyms

4930563P03Rik; AW553592;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038938

InnateDB Gene

IDBG-161408 (Ctdp1)

Protein Structure

UniProt Annotation

Function

Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Midbody {ECO:0000250}. Note=Found at centrosomes in prometaphase, at spindle and spindle poles in metaphase and at spindle midzone and midbody in anaphase and telophase-G1 respectively. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0005515	protein binding
GO:0008420	CTD phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0010458	exit from mitosis

Cellular Component

GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005819	spindle
GO:0015629	actin cytoskeleton
GO:0030496	midbody
GO:0051233	spindle midzone

Protein Structure and Domains

PDB ID

MGI:1926953

InterPro

IPR001357 BRCT domain
IPR004274 NLI interacting factor
IPR011053 Single hybrid motif
IPR011947 FCP1-like phosphatase, phosphatase domain
IPR015388 FCP1-like phosphatase, C-terminal
IPR023214 HAD-like domain

PFAM