InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Crmp1

Summary

InnateDB Protein

IDBP-158814.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Crmp1

Protein Name

collapsin response mediator protein 1

Synonyms

CRMP-1; Dpysl1; DRP-1; ULIP-3; Ulip3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031004

InnateDB Gene

IDBG-158810 (Crmp1)

Protein Structure

UniProt Annotation

Function

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis. {ECO:0000269PubMed:14685275}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Associated with centrosomes and the mitotic spindle during metaphase. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016787	hydrolase activity
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0051219	phosphoprotein binding