InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Crmp1

Summary

InnateDB Gene

IDBG-158810.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Crmp1

Gene Name

collapsin response mediator protein 1

Synonyms

CRMP-1; Dpysl1; DRP-1; ULIP-3; Ulip3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029121

Encoded Proteins

IDBP-158814

collapsin response mediator protein 1

IDBP-252355

collapsin response mediator protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that is part of the collapsin response mediator protein family. The family is comprised of five, homologous cytosolic phosphoproteins that are expressed in developing and adult nervous tissue and mediate signaling to transduce responses to extracellular cues. This protein is a Semaphorin 3A signaling molecule that regulates collapse of the growth cone. The growth cone mediates axonal pathfinding in neurons. This protein is reported to represent a new class of microtubule-associated proteins. In humans this protein is reported to inhibit cancer cell invasion. In mouse deficiency of this gene may be associated with impaired spatial memory performance. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:37242080-37292132

Strand

Forward strand

Band

Transcripts

ENSMUST00000031004	ENSMUSP00000031004
ENSMUST00000114158	ENSMUSP00000109795

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0051219	phosphoprotein binding

Biological Process

GO:0006208	pyrimidine nucleobase catabolic process
GO:0048666	neuron development

Cellular Component

GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005819	spindle
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000072832

View Gene Order

ENSBTAG00000004292

Not yet available

Pathways

NETPATH

REACTOME

REACT_261444

Axon guidance pathway

REACT_188576

Developmental Biology pathway

REACT_263034

Semaphorin interactions pathway

REACT_244852

CRMPs in Sema3A signaling pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_19199

CRMPs in Sema3A signaling pathway

REACT_111045

Developmental Biology pathway

REACT_19271

Semaphorin interactions pathway

REACT_18266

Axon guidance pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

Q3TXY0 Q6P1J1 Q71H75

UniProt Splice Variant

Entrez Gene

12933

UniGene

Mm.290995

RefSeq

NM_001136058 NM_007765

OMIM

CCDS

CCDS51481 CCDS39075

HPRD

IMGT

MGI ID

MGI:107793

MGI Symbol

Crmp1

EMBL

AC111129 AF501323 AK159049 BC065046

GenPept

AAH65046 AAQ07443 BAE34784

RNA Seq Atlas

12933