InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ndrg2

Summary

InnateDB Protein

IDBP-157753.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndrg2

Protein Name

N-myc downstream regulated gene 2

Synonyms

AI182517; AU040374; Ndr2; SYLD;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000004673

InnateDB Gene

IDBG-157751 (Ndrg2)

Protein Structure

UniProt Annotation

Function

Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:14985363, ECO:0000269PubMed:16520977}. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at highest levels in brain, heart and liver, and at lower levels in kidney, colon, skeletal muscle, adrenal gland, ovary and uterus (at protein level). {ECO:0000269PubMed:15461589, ECO:0000269PubMed:16520977, ECO:0000269PubMed:21636852}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001818	negative regulation of cytokine production
GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0010574	regulation of vascular endothelial growth factor production
GO:0016055	Wnt signaling pathway
GO:0021762	substantia nigra development
GO:0030154	cell differentiation
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0090361	regulation of platelet-derived growth factor production

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0030426	growth cone
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome