InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fgfr3

Summary

InnateDB Protein

IDBP-153746.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fgfr3

Protein Name

fibroblast growth factor receptor 3

Synonyms

CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3; sam3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070998

InnateDB Gene

IDBG-153744 (Fgfr3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005007	fibroblast growth factor-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017134	fibroblast growth factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000165	MAPK cascade
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002009	morphogenesis of an epithelium
GO:0002089	lens morphogenesis in camera-type eye
GO:0006468	protein phosphorylation
GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010518	positive regulation of phospholipase activity
GO:0014003	oligodendrocyte development
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021762	substantia nigra development
GO:0022010	central nervous system myelination
GO:0030154	cell differentiation
GO:0030900	forebrain development
GO:0031398	positive regulation of protein ubiquitination
GO:0035019	somatic stem cell maintenance
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043410	positive regulation of MAPK cascade
GO:0043525	positive regulation of neuron apoptotic process
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045597	positive regulation of cell differentiation
GO:0045839	negative regulation of mitosis
GO:0045879	negative regulation of smoothened signaling pathway
GO:0046777	protein autophosphorylation
GO:0048546	digestive tract morphogenesis
GO:0048678	response to axon injury
GO:0048712	negative regulation of astrocyte differentiation
GO:0048839	inner ear development
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051216	cartilage development
GO:0060113	inner ear receptor cell differentiation
GO:0060349	bone morphogenesis
GO:0060385	axonogenesis involved in innervation
GO:0061144	alveolar secondary septum development
GO:0070307	lens fiber cell development
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0072148	epithelial cell fate commitment
GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0090102	cochlea development
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:1902178	fibroblast growth factor receptor apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005764	lysosome
GO:0005887	integral component of plasma membrane
GO:0009898	cytoplasmic side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:95524

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
IPR016248 Fibroblast growth factor receptor family
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF07679
PF00047

PRINTS

PR00109

PIRSF

PIRSF000628

SMART

SM00220
SM00408
SM00409
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References