Version 5.4
Mus musculus Gene: Fgfr3
Summary
InnateDB Gene IDBG-153744.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fgfr3
Gene Name fibroblast growth factor receptor 3
Synonyms CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3; sam3
Species Mus musculus
Ensembl Gene ENSMUSG00000054252
Encoded Proteins
IDBP-153746
fibroblast growth factor receptor 3
IDBP-153748
fibroblast growth factor receptor 3
IDBP-251812
fibroblast growth factor receptor 3
IDBP-540703
fibroblast growth factor receptor 3
IDBP-626607
fibroblast growth factor receptor 3
IDBP-626609
fibroblast growth factor receptor 3
IDBP-626610
fibroblast growth factor receptor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the fibroblast growth factor receptor family. Members of this family are highly conserved proteins that differ from one another in their ligand affinities and tissue distribution. A representative protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene may be associated with craniosynostosis and multiple types of skeletal dysplasia. A pseudogene of this gene is located on chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:33721724-33737068
Strand Forward strand
Band B2
Transcripts
ENSMUST00000067150 ENSMUSP00000070998
ENSMUST00000087820 ENSMUSP00000085122
ENSMUST00000114411 ENSMUSP00000110053
ENSMUST00000134610
ENSMUST00000155002 ENSMUSP00000119941
ENSMUST00000132724
ENSMUST00000152661
ENSMUST00000142860
ENSMUST00000169212 ENSMUSP00000130856
ENSMUST00000164207 ENSMUSP00000133064
ENSMUST00000171509 ENSMUSP00000131845
ENSMUST00000181298
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005007 fibroblast growth factor-activated receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017134 fibroblast growth factor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000165 MAPK cascade
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002009 morphogenesis of an epithelium
GO:0002089 lens morphogenesis in camera-type eye
GO:0006468 protein phosphorylation
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010518 positive regulation of phospholipase activity
GO:0014003 oligodendrocyte development
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021762 substantia nigra development
GO:0022010 central nervous system myelination
GO:0030154 cell differentiation
GO:0030900 forebrain development
GO:0031398 positive regulation of protein ubiquitination
GO:0035019 somatic stem cell maintenance
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043410 positive regulation of MAPK cascade
GO:0043525 positive regulation of neuron apoptotic process
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045597 positive regulation of cell differentiation
GO:0045839 negative regulation of mitosis
GO:0045879 negative regulation of smoothened signaling pathway
GO:0046777 protein autophosphorylation
GO:0048546 digestive tract morphogenesis
GO:0048678 response to axon injury
GO:0048712 negative regulation of astrocyte differentiation
GO:0048839 inner ear development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051216 cartilage development
GO:0060113 inner ear receptor cell differentiation
GO:0060349 bone morphogenesis
GO:0060385 axonogenesis involved in innervation
GO:0061144 alveolar secondary septum development
GO:0070307 lens fiber cell development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0072148 epithelial cell fate commitment
GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0090102 cochlea development
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1902178 fibroblast growth factor receptor apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005887 integral component of plasma membrane
GO:0009898 cytoplasmic side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000068078
View Gene Order
ENSBTAG00000007164
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05219
Bladder cancer pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04010
MAPK signaling pathway pathway
mmu04144
Endocytosis pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121337
Signaling by activated point mutants of FGFR3 pathway
REACT_121011
t(4;14) translocations of FGFR3 pathway
REACT_121398
Signaling by FGFR mutants pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_121249
Signaling by FGFR3 mutants pathway
REACT_116125
Disease pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04010
MAPK signaling pathway pathway
hsa05219
Bladder cancer pathway
hsa04144
Endocytosis pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
FGF signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
fgf_pathway
FGF signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.395258 Mm.488649 Mm.6904
RefSeq NM_001163215 NM_001163216 NM_001163217 NM_001205270 NM_008010 XM_006503713 XM_006503714 XM_006503715 XM_006503716 XM_006503717 XM_006503718 XM_006503719 XM_006503720 XM_006503721 XM_006503722 XM_006503725 XM_006503726 XM_006503727 XM_006503728 XM_006503731 XM_006503732
OMIM
CCDS CCDS51465 CCDS51466 CCDS57335
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca