InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eif2s1

Summary

InnateDB Protein

IDBP-152189.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif2s1

Protein Name

eukaryotic translation initiation factor 2, subunit 1 alpha

Synonyms

0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a; eIF2alpha;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071214

InnateDB Gene

IDBG-152187 (Eif2s1)

Protein Structure

UniProt Annotation

Function

Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasmic granule {ECO:0000269PubMed:19861488}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity
GO:0005515	protein binding
GO:0043022	ribosome binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006412	translation
GO:0006413	translational initiation
GO:0043558	regulation of translational initiation in response to stress
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005850	eukaryotic translation initiation factor 2 complex
GO:0005851	eukaryotic translation initiation factor 2B complex
GO:0010494	cytoplasmic stress granule
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:95299

InterPro

IPR003029 Ribosomal protein S1, RNA-binding domain
IPR011488 Translation initiation factor 2, alpha subunit
IPR012340 Nucleic acid-binding, OB-fold
IPR022967 RNA-binding domain, S1
IPR024054 Translation initiation factor 2, alpha subunit, middle domain
IPR024055 Translation initiation factor 2, alpha subunit, C-terminal

PFAM

PF00575
PF07541

PRINTS

PIRSF

SMART

SM00316

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6ZWX6