Version 5.4
Mus musculus Gene: Eif2s1
Summary
InnateDB Gene IDBG-152187.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif2s1
Gene Name eukaryotic translation initiation factor 2, subunit 1 alpha
Synonyms 0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a; eIF2alpha
Species Mus musculus
Ensembl Gene ENSMUSG00000021116
Encoded Proteins
IDBP-152189
eukaryotic translation initiation factor 2, subunit 1 alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134001:
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:78861819-78887010
Strand Forward strand
Band C3
Transcripts
ENSMUST00000071230 ENSMUSP00000071214
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0043022 ribosome binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
GO:0006413 translational initiation
GO:0043558 regulation of translational initiation in response to stress
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0005851 eukaryotic translation initiation factor 2B complex
GO:0010494 cytoplasmic stress granule
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134001
View Gene Order
ENSBTAG00000016311
Not yet available
Pathways
NETPATH
REACTOME
REACT_255163
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_239697
Unfolded Protein Response (UPR) pathway
REACT_254308
Translation pathway
REACT_256488
Translation initiation complex formation pathway
REACT_247926
Metabolism of proteins pathway
REACT_229570
Cap-dependent Translation Initiation pathway
REACT_243361
PERK regulates gene expression pathway
REACT_262064
Eukaryotic Translation Initiation pathway
REACT_233572
Gene Expression pathway
REACT_259469
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_236458
Ribosomal scanning and start codon recognition pathway
REACT_262078
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_229709
Recycling of eIF2:GDP pathway
REACT_249316
Formation of the ternary complex, and subsequently, the 43S complex pathway
KEGG
mmu03013
RNA transport pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
mmu05160
Hepatitis C pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_13
IL1 pathway
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_18277
PERK regulates gene expression pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_1079
Formation of the ternary complex, and subsequently, the 43S complex pathway
REACT_1815
Recycling of eIF2:GDP pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
REACT_207291
PERK regulates gene expression pathway
REACT_203882
Formation of the ternary complex, and subsequently, the 43S complex pathway
REACT_246268
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_226022
Gene Expression pathway
REACT_218564
Eukaryotic Translation Initiation pathway
REACT_225918
Cap-dependent Translation Initiation pathway
REACT_209048
Translation pathway
REACT_206472
Recycling of eIF2:GDP pathway
REACT_202903
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_213782
Metabolism of proteins pathway
REACT_220444
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_224343
Translation initiation complex formation pathway
REACT_226614
Unfolded Protein Response (UPR) pathway
REACT_222420
Ribosomal scanning and start codon recognition pathway
KEGG
hsa03013
RNA transport pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt Q6ZWX6
TrEMBL Q9CV24
UniProt Splice Variant
Entrez Gene 13665
UniGene Mm.196220 Mm.405568 Mm.412353
RefSeq NM_026114
OMIM
CCDS CCDS26003
HPRD
IMGT
MGI ID MGI:95299
MGI Symbol Eif2s1
EMBL AK009934 AK010592 AK143499 AK167763 BC005463 BC016448 BC016497
GenPept AAH05463 AAH16448 AAH16497 BAB26593 BAB27049 BAE25400 BAE39796
RNA Seq Atlas 13665

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca