InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppil2

Summary

InnateDB Protein

IDBP-137981.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppil2

Protein Name

peptidylprolyl isomerase (cyclophilin)-like 2

Synonyms

0610009L05Rik; 1700016N17Rik; 4921520K19Rik; 4930511F14Rik; AA589416; C130078A06Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023455

InnateDB Gene

IDBG-137979 (Ppil2)

Protein Structure

UniProt Annotation

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0034450	ubiquitin-ubiquitin ligase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0000413	protein peptidyl-prolyl isomerization
GO:0006457	protein folding
GO:0016567	protein ubiquitination

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

MGI:2447857

InterPro

IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
IPR003613 U box domain
IPR027799 Replication termination factor 2, RING-finger
IPR029000 Cyclophilin-like domain

PFAM

PF00160
PF04564
PF04641

PRINTS

PR00153

PIRSF

SMART

SM00504

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt