Version 5.4
Mus musculus Gene: Ppil2
Summary
InnateDB Gene IDBG-137979.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppil2
Gene Name peptidylprolyl isomerase (cyclophilin)-like 2
Synonyms 0610009L05Rik; 1700016N17Rik; 4921520K19Rik; 4930511F14Rik; AA589416; C130078A06Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000022771
Encoded Proteins
IDBP-137981
peptidylprolyl isomerase (cyclophilin)-like 2
IDBP-249025
peptidylprolyl isomerase (cyclophilin)-like 2
IDBP-249027
peptidylprolyl isomerase (cyclophilin)-like 2
IDBP-625343
peptidylprolyl isomerase (cyclophilin)-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100023:
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:17086555-17111257
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000023455 ENSMUSP00000023455
ENSMUST00000115721 ENSMUSP00000111386
ENSMUST00000115719 ENSMUSP00000111384
ENSMUST00000146151
ENSMUST00000143519
ENSMUST00000124030
ENSMUST00000141129
ENSMUST00000156521
ENSMUST00000153927
ENSMUST00000134849
ENSMUST00000153368
ENSMUST00000164458 ENSMUSP00000131422
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0034450 ubiquitin-ubiquitin ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0016567 protein ubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100023
View Gene Order
ENSBTAG00000021121
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_211508
Basigin interactions pathway
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12560
Basigin interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_604
Hemostasis pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3YZQ4
UniProt Splice Variant
Entrez Gene 66053
UniGene Mm.253614 Mm.448518 Mm.489721
RefSeq NM_001252444 NM_001252445 NM_144954 XM_006522444 XM_006522445 XM_006522446 XM_006522447
OMIM
CCDS CCDS27993
HPRD
IMGT
MGI ID MGI:2447857
MGI Symbol Ppil2
EMBL AC154667
GenPept
RNA Seq Atlas 66053

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca