Homo sapiens Gene: NHP2L1
Summary
InnateDB Gene IDBG-9368.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NHP2L1
Gene Name NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
Synonyms 15.5K; FA-1; FA1; NHPX; OTK27; SNRNP15-5; SNU13; SPAG12; SSFA1;
Species Homo sapiens
Ensembl Gene ENSG00000100138
Encoded Proteins
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5\' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:41673930-41690504
Strand Reverse strand
Band q13.2
Transcripts
ENST00000355257 ENSP00000347401
ENST00000215956 ENSP00000215956
ENST00000402458 ENSP00000383989
ENST00000401959 ENSP00000383949
ENST00000463675
ENST00000488571
ENST00000469028
ENST00000469522
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 121 experimentally validated interaction(s) in this database.
Experimentally validated
Total 121 [view]
Protein-Protein 120 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030515 snoRNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
GO:0030529 ribonucleoprotein complex
GO:0031428 box C/D snoRNP complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
mRNA Splicing - Minor Pathway pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
mRNA Splicing pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
KEGG
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001003796 NM_005008 XM_005261620 XM_006724258
HUGO
OMIM
CCDS CCDS14022 CCDS33653
HPRD 03197
IMGT
EMBL
GenPept
RNA Seq Atlas