InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NHP2L1

Summary

InnateDB Protein

IDBP-293239.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NHP2L1

Protein Name

NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)

Synonyms

15.5K; FA-1; FA1; NHPX; OTK27; SNRNP15-5; SNU13; SPAG12; SSFA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000383949

InnateDB Gene

IDBG-9368 (NHP2L1)

Protein Structure

UniProt Annotation

Function

Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. {ECO:0000269PubMed:10545122, ECO:0000269PubMed:17412961}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:10593953, ECO:0000269PubMed:12429849, ECO:0000269Ref.7}. Note=Concentrated in the dense fibrillar component of the nucleolus.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 121 experimentally validated interaction(s) in this database.

Experimentally validated
Total	121 [view]
Protein-Protein	120 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0030515	snoRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0042254	ribosome biogenesis

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005730	nucleolus
GO:0031428	box C/D snoRNP complex

Protein Structure and Domains

PDB ID

InterPro

IPR000948 Ribosomal protein L7Ae, prokaryotes
IPR002415 H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote
IPR004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
IPR013241 RNase P, subunit Pop3
IPR018492 Ribosomal protein L7Ae/L8/Nhp2 family
IPR029064 50S ribosomal protein L30e-like

PFAM

PF01248
PF08228

PRINTS

PR00884
PR00883
PR00881

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P55769