Version 5.4
Homo sapiens Gene: GRK4
Summary
InnateDB Gene IDBG-7807.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRK4
Gene Name G protein-coupled receptor kinase 4
Synonyms GPRK2L; GPRK4; GRK4a; IT11
Species Homo sapiens
Ensembl Gene ENSG00000125388
Encoded Proteins
IDBP-7811
G protein-coupled receptor kinase 4
IDBP-233961
G protein-coupled receptor kinase 4
IDBP-233963
G protein-coupled receptor kinase 4
IDBP-477413
G protein-coupled receptor kinase 4
IDBP-474411
G protein-coupled receptor kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. [provided by RefSeq, Jul 2008]
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:2963608-3040747
Strand Forward strand
Band p16.3
Transcripts
ENST00000345167 ENSP00000264764
ENST00000398052 ENSP00000381129
ENST00000398051 ENSP00000381128
ENST00000503518 ENSP00000421650
ENST00000504933 ENSP00000427445
ENST00000507230
ENST00000505271
ENST00000511827
ENST00000509545
ENST00000504308
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 7 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004703 G-protein coupled receptor kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0050254 rhodopsin kinase activity
Biological Process
GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway
GO:0002031 G-protein coupled receptor internalization
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0031623 receptor internalization
GO:0038032 termination of G-protein coupled receptor signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0005938 cell cortex
GO:0030425 dendrite
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052783
View Gene Order
ENSBTAG00000001505
Not yet available
Pathways
NETPATH
NetPath_25
FSH pathway
REACTOME
KEGG
hsa04144
Endocytosis pathway
hsa04062
Chemokine signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.32959
RefSeq NM_001004056 NM_001004057 NM_005307 NM_182982 XM_005247961 XM_006713879
HUGO
OMIM
CCDS CCDS33946 CCDS33947 CCDS47002 CCDS68656
HPRD 00656
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca