Version 5.4
Homo sapiens Gene: TRIOBP
Summary
InnateDB Gene IDBG-6969.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIOBP
Gene Name TRIO and F-actin binding protein
Synonyms DFNB28; dJ37E16.4; TAP68; TARA
Species Homo sapiens
Ensembl Gene ENSG00000100106
Encoded Proteins
IDBP-6971
TRIO and F-actin binding protein
IDBP-293779
TRIO and F-actin binding protein
IDBP-293759
TRIO and F-actin binding protein
IDBP-293753
TRIO and F-actin binding protein
IDBP-375821
TRIO and F-actin binding protein
IDBP-375824
TRIO and F-actin binding protein
IDBP-375831
TRIO and F-actin binding protein
IDBP-375837
TRIO and F-actin binding protein
IDBP-375839
TRIO and F-actin binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:37697004-37776556
Strand Forward strand
Band q13.1
Transcripts
ENST00000344404 ENSP00000340312
ENST00000331103
ENST00000406386 ENSP00000384312
ENST00000403663 ENSP00000386026
ENST00000407319 ENSP00000383913
ENST00000428075 ENSP00000399006
ENST00000413051 ENSP00000400680
ENST00000418339 ENSP00000396946
ENST00000452519 ENSP00000407542
ENST00000417857 ENSP00000387881
ENST00000492485
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0017049 GTP-Rho binding
GO:0031625 ubiquitin protein ligase binding
GO:0045159 myosin II binding
GO:0051015 actin filament binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0030047 actin modification
GO:0051016 barbed-end actin filament capping
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0015629 actin cytoskeleton
GO:0030496 midbody
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033088
View Gene Order
ENSBTAG00000002539
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.533030 Hs.734724
RefSeq NM_001039141 NM_007032 NM_138632
HUGO
OMIM
CCDS CCDS33644 CCDS43015 CCDS43016
HPRD 11028
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca