Homo sapiens Gene: SF3A1
Summary
InnateDB Gene IDBG-4041.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SF3A1
Gene Name splicing factor 3a, subunit 1, 120kDa
Synonyms PRP21; PRPF21; SAP114; SF3A120;
Species Homo sapiens
Ensembl Gene ENSG00000099995
Encoded Proteins
splicing factor 3a, subunit 1, 120kDa
splicing factor 3a, subunit 1, 120kDa
splicing factor 3a, subunit 1, 120kDa
splicing factor 3a, subunit 1, 120kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Sf3a1 affects the mRNA splicing of genes in the TLR signalling pathway to modulate the innate immune response in macrophages.
Entrez Gene
Summary This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a subunit of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer is a component of the mature U2 small nuclear ribonucleoprotein particle (snRNP). U2 small nuclear ribonucleoproteins play a critical role in spliceosome assembly and pre-mRNA splicing. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:30331988-30356947
Strand Reverse strand
Band q12.2
Transcripts
ENST00000215793 ENSP00000215793
ENST00000411423 ENSP00000412715
ENST00000444440 ENSP00000400862
ENST00000447376 ENSP00000397267
ENST00000485618
ENST00000498259
ENST00000471037
ENST00000471342
ENST00000463818
ENST00000496189
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 149 experimentally validated interaction(s) in this database.
Experimentally validated
Total 149 [view]
Protein-Protein 144 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 4 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000389 mRNA 3'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010467 gene expression
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Processing of Capped Intron-Containing Pre-mRNA pathway
mRNA Splicing pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
KEGG
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F8WB66
UniProt Splice Variant
Entrez Gene 10291
UniGene Hs.406277 Hs.626979
RefSeq NM_005877 NM_001005409
HUGO HGNC:10765
OMIM 605595
CCDS CCDS13875
HPRD 06903
IMGT
EMBL AC004997
GenPept
RNA Seq Atlas 10291