Version 5.4
Homo sapiens Gene: WDR7
Summary
InnateDB Gene IDBG-3666.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WDR7
Gene Name WD repeat domain 7
Synonyms TRAG
Species Homo sapiens
Ensembl Gene ENSG00000091157
Encoded Proteins
IDBP-3668
WD repeat domain 7
IDBP-3670
WD repeat domain 7
IDBP-726668
IDBP-728093
IDBP-727432
IDBP-727361
IDBP-809723
WD repeat domain 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) that may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein forms the beta subunit of rabconnectin-3 and binds directly with Rab3A GDP/GTP exchange protein and indirectly with Rab3A GDP/GTP activating protein; these proteins are regulators of Rab3 small G protein family members involved in control of the calcium-dependant exocytosis of neurotransmitters. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:56651343-57036606
Strand Forward strand
Band q21.31
Transcripts
ENST00000254442 ENSP00000254442
ENST00000357574 ENSP00000350187
ENST00000593058 ENSP00000466438
ENST00000585669 ENSP00000466480
ENST00000587403
ENST00000585754
ENST00000590557
ENST00000589935 ENSP00000467485
ENST00000586124
ENST00000591524
ENST00000585824
ENST00000591449 ENSP00000467596
ENST00000615645 ENSP00000481823
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040560
View Gene Order
ENSBTAG00000004005
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.465213 Hs.635608 Hs.686448
RefSeq NM_015285 NM_052834 XM_005266674 XM_006722431
HUGO
OMIM
CCDS CCDS11962 CCDS11963
HPRD 10306
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca