Version 5.4
Homo sapiens Gene: KDM5D
Summary
InnateDB Gene IDBG-354.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KDM5D
Gene Name lysine (K)-specific demethylase 5D
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000012817
Encoded Proteins
IDBP-358
lysine (K)-specific demethylase 5D
IDBP-360
lysine (K)-specific demethylase 5D
IDBP-362445
lysine (K)-specific demethylase 5D
IDBP-362452
lysine (K)-specific demethylase 5D
IDBP-362455
lysine (K)-specific demethylase 5D
IDBP-598075
lysine (K)-specific demethylase 5D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome Y:19703865-19744939
Strand Reverse strand
Band q11.223
Transcripts
ENST00000317961 ENSP00000322408
ENST00000382806 ENSP00000372256
ENST00000440077 ENSP00000398543
ENST00000415360 ENSP00000389433
ENST00000447300 ENSP00000416377
ENST00000492117
ENST00000469599
ENST00000485154
ENST00000478891
ENST00000541639 ENSP00000444293
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0032453 histone demethylase activity (H3-K4 specific)
Biological Process
GO:0034720 histone H3-K4 demethylation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005575 cellular_component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_228178
HDMs demethylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.630488 Hs.80358
RefSeq NM_001146705 NM_001146706 NM_004653 XM_005262563
HUGO
OMIM
CCDS CCDS14794 CCDS55554 CCDS55555
HPRD 02464
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca