Version 5.4
Homo sapiens Gene: EFS
Summary
InnateDB Gene IDBG-3201.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EFS
Gene Name embryonal Fyn-associated substrate
Synonyms CAS3; CASS3; EFS1; EFS2; HEFS; SIN
Species Homo sapiens
Ensembl Gene ENSG00000100842
Encoded Proteins
IDBP-3203
embryonal Fyn-associated substrate
IDBP-3205
embryonal Fyn-associated substrate
IDBP-362195
embryonal Fyn-associated substrate
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The longest protein isoform encoded by this gene contains an SH3 domain, which is known to be important in intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to bind to SH3 domains of protein-tyrosine kinases. The function of this gene is unknown. Three alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:23356402-23365752
Strand Reverse strand
Band q11.2
Transcripts
ENST00000216733 ENSP00000216733
ENST00000351354 ENSP00000340607
ENST00000429593 ENSP00000416684
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0019904 protein domain specific binding
Biological Process
GO:0007155 cell adhesion
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022203
View Gene Order
ENSBTAG00000038733
Not yet available
Cross-References
SwissProt O43281
TrEMBL
UniProt Splice Variant
Entrez Gene 10278
UniGene Hs.24587
RefSeq NM_001277174 NM_005864 NM_032459
HUGO HGNC:16898
OMIM 609906
CCDS CCDS61404 CCDS9595 CCDS9596
HPRD
IMGT
EMBL AB001466 AB001467 AK295933 AK314221 AL049829 BC034246 CH471078
GenPept AAH34246 BAA24588 BAA24589 BAG36894 BAG58718 EAW66164
RNA Seq Atlas 10278

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca