Version 5.4
Homo sapiens Protein: EFS
Summary
InnateDB Protein IDBP-3203.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EFS
Protein Name embryonal Fyn-associated substrate
Synonyms CAS3; CASS3; EFS1; EFS2; HEFS; SIN;
Species Homo sapiens
Ensembl Protein ENSP00000216733
InnateDB Gene IDBG-3201 (EFS)
Protein Structure
UniProt Annotation
Function Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity The protein has been detected in lung and placenta.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0019904 protein domain specific binding
Biological Process
GO:0007155 cell adhesion
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR011511 Variant SH3 domain
IPR021901 CAS family, DUF3513
PFAM PF00018
PF14604
PF07653
PF12026
PRINTS PR00452
PIRSF
SMART SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43281
PhosphoSite PhosphoSite-O43281
TrEMBL
UniProt Splice Variant
Entrez Gene 10278
UniGene Hs.24587
RefSeq NP_005855
HUGO HGNC:16898
OMIM 609906
CCDS CCDS9595
HPRD 09932
IMGT
EMBL AB001466 AB001467 AK295933 AK314221 AL049829 BC034246 CH471078
GenPept AAH34246 BAA24588 BAA24589 BAG36894 BAG58718 EAW66164

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca