Homo sapiens Gene: CABIN1
Summary
InnateDB Gene IDBG-2725.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CABIN1
Gene Name calcineurin binding protein 1
Synonyms CAIN; PPP3IN;
Species Homo sapiens
Ensembl Gene ENSG00000099991
Encoded Proteins
calcineurin binding protein 1
calcineurin binding protein 1
calcineurin binding protein 1
calcineurin binding protein 1
calcineurin binding protein 1
calcineurin binding protein 1
calcineurin binding protein 1
calcineurin binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:24011192-24178628
Strand Forward strand
Band q11.23
Transcripts
ENST00000263119 ENSP00000263119
ENST00000337989 ENSP00000336991
ENST00000398319 ENSP00000381364
ENST00000405822 ENSP00000384694
ENST00000454754 ENSP00000394209
ENST00000445422 ENSP00000412389
ENST00000474981
ENST00000484593
ENST00000496016
ENST00000467937
ENST00000495121
ENST00000485008
ENST00000459824
ENST00000617531 ENSP00000480560
ENST00000620406 ENSP00000481128
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004864 protein phosphatase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0006336 DNA replication-independent nucleosome assembly
GO:0007166 cell surface receptor signaling pathway
GO:0016568 chromatin modification
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016235 aggresome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
TCR pathway
REACTOME
Cellular responses to stress pathway
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Cellular Senescence pathway
KEGG
INOH
PID BIOCARTA
Role of mef2d in t-cell apoptosis [Biocarta view]
Control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) [Biocarta view]
PID NCI
Calcium signaling in the CD4+ TCR pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.517478 Hs.735702
RefSeq NM_001199281 NM_001201429 NM_012295 XM_005261417 XM_006724184
HUGO
OMIM
CCDS CCDS13823 CCDS74830
HPRD 10369
IMGT
EMBL
GenPept
RNA Seq Atlas