Mus musculus Gene: Cabin1
Summary
InnateDB Gene IDBG-163386.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cabin1
Gene Name calcineurin binding protein 1
Synonyms A330070M20Rik; Cain; Ppp3in
Species Mus musculus
Ensembl Gene ENSMUSG00000020196
Encoded Proteins
calcineurin binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099991:
Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:75646110-75764357
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000001712 ENSMUSP00000001712
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004864 protein phosphatase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0006336 DNA replication-independent nucleosome assembly
GO:0007165 signal transduction
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016235 aggresome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
TCR pathway
REACTOME
Cellular responses to stress pathway
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Cellular Senescence pathway
KEGG
INOH
PID NCI
Calcium signaling in the CD4+ TCR pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Cross-References
SwissProt
TrEMBL G3X8Q1 Q3TGB0 Q80X22
UniProt Splice Variant
Entrez Gene 104248
UniGene Mm.257404 Mm.453198
RefSeq NM_172549 XM_006513019 XM_006513022
OMIM
CCDS CCDS35938
HPRD
IMGT
MGI ID MGI:1298375
MGI Symbol Cabin1
EMBL AC087540 AC142499 AK168811 BC051668 CH466553
GenPept AAH51668 BAE40638 EDL31891
RNA Seq Atlas 104248