Homo sapiens Gene: C3
Summary
InnateDB Gene IDBG-21798.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C3
Gene Name complement component 3
Synonyms AHUS5; ARMD9; ASP; C3a; C3b; CPAMD1; HEL-S-62p;
Species Homo sapiens
Ensembl Gene ENSG00000125730
Encoded Proteins
complement component 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Central protein of the complement system; Classical, lectin and alternative pathways of complement all converge at the activation of C3 yielding a diverse set of biological responses
T cell-expressed CTSL1 cleaves C3 into active C3a and C3b fragments mediating the intracellular and extracellular C3 activation in T cells.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] C3a and its receptor C3ar1 are critical for defense against C. psittaci in mouse lung infection.
Entrez Gene
Summary Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:6677704-6730562
Strand Reverse strand
Band p13.3
Transcripts
ENST00000245907 ENSP00000245907
ENST00000596179
ENST00000602053
ENST00000597442
ENST00000601475
ENST00000599668
ENST00000602229 ENSP00000469482
ENST00000599899
ENST00000594005
ENST00000598805
ENST00000601008 ENSP00000471384
ENST00000600763
ENST00000596238
ENST00000596548 ENSP00000469744
ENST00000594936
ENST00000594270
ENST00000595577
ENST00000600744 ENSP00000472044
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 36 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0031715 C5L2 anaphylatoxin chemotactic receptor binding
Biological Process
GO:0001798 positive regulation of type IIa hypersensitivity
GO:0001934 positive regulation of protein phosphorylation
GO:0001970 positive regulation of activation of membrane attack complex
GO:0006631 fatty acid metabolic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0010828 positive regulation of glucose transport
GO:0010866 regulation of triglyceride biosynthetic process
GO:0010884 positive regulation of lipid storage
GO:0010951 negative regulation of endopeptidase activity
GO:0030449 regulation of complement activation
GO:0045087 innate immune response (InnateDB)
GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0050766 positive regulation of phagocytosis
GO:0050776 regulation of immune response
GO:2000427 positive regulation of apoptotic cell clearance
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Alternative complement activation pathway
Signaling by GPCR pathway
Innate Immune System pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Immune System pathway
Activation of C3 and C5 pathway
Regulation of Complement cascade pathway
Complement cascade pathway
GPCR ligand binding pathway
Initial triggering of complement pathway
KEGG
Phagosome pathway
Complement and coagulation cascades pathway
Leishmaniasis pathway
Chagas disease (American trypanosomiasis) pathway
Staphylococcus aureus infection pathway
Systemic lupus erythematosus pathway
INOH
PID BIOCARTA
Alternative complement pathway [Biocarta view]
Classical complement pathway [Biocarta view]
Lectin induced complement pathway [Biocarta view]
PID NCI
Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha network
Beta2 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.529053
RefSeq NM_000064
HUGO
OMIM
CCDS CCDS32883
HPRD 00400
IMGT
EMBL
GenPept
RNA Seq Atlas