InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.19562

Summary

InnateDB Gene

IDBG-643930.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.19562

Gene Name

complement C3 preproprotein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017280

Encoded Proteins

IDBP-696536

complement C3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 16875735

[Homo sapiens] Central protein of the complement system; Classical, lectin and alternative pathways of complement all converge at the activation of C3 yielding a diverse set of biological responses

PMID 24315997

[Homo sapiens] T cell-expressed CTSL1 cleaves C3 into active C3a and C3b fragments mediating the intracellular and extracellular C3 activation in T cells.

PMID 24273177

[Mus musculus] C3a and its receptor C3ar1 are critical for defense against C. psittaci in mouse lung infection.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125730:
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:18989689-19025591

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022979

ENSBTAP00000022979

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004866	endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0031715	C5L2 anaphylatoxin chemotactic receptor binding

Biological Process

GO:0001798	positive regulation of type IIa hypersensitivity
GO:0001934	positive regulation of protein phosphorylation
GO:0001970	positive regulation of activation of membrane attack complex
GO:0006954	inflammatory response
GO:0006956	complement activation
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0010828	positive regulation of glucose transport
GO:0010866	regulation of triglyceride biosynthetic process
GO:0010884	positive regulation of lipid storage
GO:0010951	negative regulation of endopeptidase activity
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway
GO:0045766	positive regulation of angiogenesis
GO:0050766	positive regulation of phagocytosis
GO:2000427	positive regulation of apoptotic cell clearance