Version 5.4
Homo sapiens Gene: NEO1
Summary
InnateDB Gene IDBG-20957.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEO1
Gene Name neogenin 1
Synonyms IGDCC2; NGN; NTN1R2
Species Homo sapiens
Ensembl Gene ENSG00000067141
Encoded Proteins
IDBP-20959
neogenin 1
IDBP-20961
neogenin 1
IDBP-599234
neogenin 1
IDBP-592081
neogenin 1
IDBP-600133
neogenin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:73051710-73305206
Strand Forward strand
Band q24.1
Transcripts
ENST00000261908 ENSP00000261908
ENST00000339362 ENSP00000341198
ENST00000560262 ENSP00000453317
ENST00000558964 ENSP00000453200
ENST00000558485
ENST00000560328 ENSP00000454024
ENST00000560352
ENST00000560407
ENST00000558807
ENST00000560808
ENST00000558886
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0045296 cadherin binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007155 cell adhesion
GO:0007411 axon guidance
GO:0007520 myoblast fusion
GO:0042692 muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0055072 iron ion homeostasis
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032340
View Gene Order
ENSBTAG00000004990
Not yet available
Pathways
NETPATH
REACTOME
REACT_21402
CDO in myogenesis pathway
REACT_22237
Netrin-1 signaling pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
REACT_21303
Myogenesis pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.388613 Hs.639053 Hs.715703
RefSeq NM_001172623 NM_001172624 NM_002499 XM_005254412 XM_005254413 XM_005254414 XM_005254416
HUGO
OMIM
CCDS CCDS10247 CCDS53957 CCDS58378
HPRD 03549
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca