InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NEO1

Summary

InnateDB Protein

IDBP-599234.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NEO1

Protein Name

neogenin 1

Synonyms

IGDCC2; NGN; NTN1R2;

Species

Homo sapiens

Ensembl Protein

ENSP00000453317

InnateDB Gene

IDBG-20957 (NEO1)

Protein Structure

UniProt Annotation

Function

Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. {ECO:0000269PubMed:21149453}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Widely expressed and also in cancer cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0042692	muscle cell differentiation
GO:0051149	positive regulation of muscle cell differentiation
GO:0055072	iron ion homeostasis

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR010560 Neogenin, C-terminal
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF00041
PF01108
PF06583
PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q92859