Version 5.4
Homo sapiens Gene: IQSEC1
Summary
InnateDB Gene IDBG-19527.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IQSEC1
Gene Name IQ motif and Sec7 domain 1
Synonyms ARF-GEP100; ARFGEP100; BRAG2; GEP100
Species Homo sapiens
Ensembl Gene ENSG00000144711
Encoded Proteins
IDBP-19529
IQ motif and Sec7 domain 1
IDBP-806832
IQ motif and Sec7 domain 1
IDBP-806833
IQ motif and Sec7 domain 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:12897220-13073117
Strand Reverse strand
Band p25.2
Transcripts
ENST00000273221 ENSP00000273221
ENST00000473088
ENST00000474467
ENST00000618604 ENSP00000478001
ENST00000613206 ENSP00000480301
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0030036 actin cytoskeleton organization
GO:0032012 regulation of ARF protein signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005730 nucleolus
GO:0016020 membrane
GO:0030054 cell junction
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034312
View Gene Order
ENSBTAG00000003237
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
plexind1_pathway
Plexin-D1 Signaling
arf6_pathway
Arf6 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001134382 NM_014869
HUGO
OMIM
CCDS CCDS33703 CCDS74902
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca