InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NUP155

Summary

InnateDB Gene

IDBG-17015.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUP155

Gene Name

nucleoporin 155kDa

Synonyms

ATFB15; N155

Species

Homo sapiens

Ensembl Gene

ENSG00000113569

Encoded Proteins

IDBP-17017

nucleoporin 155kDa

IDBP-17019

nucleoporin 155kDa

IDBP-481548

nucleoporin 155kDa

IDBP-481486

nucleoporin 155kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Nucleoporins are the main components of the nuclear pore complex (NPC) of eukaryotic cells. They are involved in the bidirectional trafficking of molecules, especially mRNAs and proteins, between the nucleus and the cytoplasm. The protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. Two protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:37288137-37371181

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000381843	ENSP00000371265
ENST00000231498	ENSP00000231498
ENST00000508182
ENST00000502533
ENST00000513532	ENSP00000422019
ENST00000515054
ENST00000507233
ENST00000507675	ENSP00000423484

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0017056	structural constituent of nuclear pore

Biological Process

GO:0000278	mitotic cell cycle
GO:0005975	carbohydrate metabolic process
GO:0006406	mRNA export from nucleus
GO:0006606	protein import into nucleus
GO:0006913	nucleocytoplasmic transport
GO:0006998	nuclear envelope organization
GO:0007077	mitotic nuclear envelope disassembly
GO:0008645	hexose transport
GO:0010827	regulation of glucose transport
GO:0015758	glucose transport
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport
GO:0086014	atrial cardiac muscle cell action potential