InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUP155

Summary

InnateDB Protein

IDBP-17019.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUP155

Protein Name

nucleoporin 155kDa

Synonyms

ATFB15; N155;

Species

Homo sapiens

Ensembl Protein

ENSP00000231498

InnateDB Gene

IDBG-17015 (NUP155)

Protein Structure

UniProt Annotation

Function

Essential component of nuclear pore complex. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nuclear pore complex {ECO:0000250}. Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Nucleoplasmic side {ECO:0000250}. Note=In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0017056	structural constituent of nuclear pore

Biological Process

GO:0000278	mitotic cell cycle
GO:0005975	carbohydrate metabolic process
GO:0006406	mRNA export from nucleus
GO:0006606	protein import into nucleus
GO:0006998	nuclear envelope organization
GO:0007077	mitotic nuclear envelope disassembly
GO:0008645	hexose transport
GO:0010827	regulation of glucose transport
GO:0015758	glucose transport
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport
GO:0086014	atrial cardiac muscle cell action potential