Version 5.4
Homo sapiens Gene: CPSF2
Summary
InnateDB Gene IDBG-16891.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPSF2
Gene Name cleavage and polyadenylation specific factor 2, 100kDa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165934
Encoded Proteins
IDBP-16893
cleavage and polyadenylation specific factor 2, 100kDa
IDBP-600222
cleavage and polyadenylation specific factor 2, 100kDa
IDBP-595307
cleavage and polyadenylation specific factor 2, 100kDa
IDBP-586758
cleavage and polyadenylation specific factor 2, 100kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:92121937-92172145
Strand Forward strand
Band q32.12
Transcripts
ENST00000298875 ENSP00000298875
ENST00000553427 ENSP00000451418
ENST00000554290 ENSP00000452503
ENST00000556622
ENST00000555244 ENSP00000451390
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 51 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006366 transcription from RNA polymerase II promoter
GO:0006369 termination of RNA polymerase II transcription
GO:0006378 mRNA polyadenylation
GO:0006379 mRNA cleavage
GO:0006398 histone mRNA 3'-end processing
GO:0006406 mRNA export from nucleus
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0031124 mRNA 3'-end processing
Cellular Component
GO:0005654 nucleoplasm
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041781
View Gene Order
ENSBTAG00000010227
Not yet available
Pathways
NETPATH
REACTOME
REACT_1096
Processing of Intronless Pre-mRNAs pathway
REACT_1849
mRNA 3'-end processing pathway
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_1835
Transport of Mature mRNA Derived from an Intronless Transcript pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_387
Cleavage of Growing Transcript in the Termination Region pathway
REACT_894
RNA Polymerase II Transcription Termination pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_1281
Transport of Mature Transcript to Cytoplasm pathway
REACT_1768
Processing of Capped Intronless Pre-mRNA pathway
REACT_338
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
KEGG
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.657632 Hs.710170
RefSeq NM_017437 XM_005267767
HUGO
OMIM
CCDS CCDS9902
HPRD 05824
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca