InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CPSF2

Summary

InnateDB Protein

IDBP-16893.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CPSF2

Protein Name

cleavage and polyadenylation specific factor 2, 100kDa

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000298875

InnateDB Gene

IDBG-16891 (CPSF2)

Protein Structure

UniProt Annotation

Function

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing. {ECO:0000269PubMed:14749727, ECO:0000269PubMed:18688255}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	51 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0016787	hydrolase activity

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006378	mRNA polyadenylation
GO:0006379	mRNA cleavage
GO:0006398	histone mRNA 3'-end processing
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing